A history of aspirin infographic pharmaceutical journal. E29 preparation of aspirin acetylsalicylic acid and thinlayer chromatography of analgesic drugs the task to prepare a pharmaceutical compound and test its purity. Aspirin is a drug which is widely used today to deal with the symptoms of many minor illnesses ranging from general relief from aches and pain. Interestingly, aspirin was once a trademark belonging to bayer.
The addition of a chemical reagent to identify substances is a common. Organic chemistry reactions and synthesis medicinal chemistry chromatography. Synthesis of aspirin lab report and analysis odinity. Practical 6 using thin layer chromatography to separate the pigments in chlorophyll. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. For preparation of aspirin, acetic anhydride is added to the measured amount of salicylic acid. Students undertake the synthesis and analysis of aspirin. Aspirin, one of the first drugs to come into common usage, is still mostly the widely used in the world approximately 35,000 metric tonnes are produced and consumed annually, enough to make over 100 billion standard aspirin tablets every year. An ester is a compound that is formed when an acid reacts with an alcohol, oh group. Synthesis and characterization of aspirin purpose the purpose of this lab was to synthesize aspirin and measure the synthesized aspirin s purity. The knowledge organiser includes the method and apparatus diagrams and goes into more depth about filtration under reduced pressure, recrystallisation and reflux. The letter a stands for acetyl, spir is derived from the plant known as spiraea ulmaria meadowsweet, which yields salicin, and in was a common suffix used for drugs at the time of the first stable synthesis of acetylsalicylic acid. Live simple, live free tinyhouse prepper recommended for you.
H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves. Charlie archer, the oratory school, reading, 2008 aspirin is one of the most commonly used drugs in the world, so why not bring chemistry out of the text books, and synthesise aspirin in the undergraduate chemistry laboratory at reading university. Synthesizing aspirin and oil of wintergreen purpose in this experiment, you will synthesize acetylsalicylic acid, commonly known as aspirin, and methyl salicylate, oil of wintergreen, from salicylic acid. Aspirin c 9h 8o 4 is an ester formed of two substances, acetylsalicylic salicylic acid and ethanoic anhydride, by a condensation reaction. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker. A small amount of a strong acid is used as a catalyst which speeds up the reaction. The preparation and identification of a 2,4dnph derivative practical 4 the preparation of aspirin practical 5 the preparation of ethyl ethanoate practical 6. Synthesis of aspirin aspirin is the single most manufactured drug in the world. By calculating the theoretical yield based on the original amount of salicylic acid, one could determine the actual yield percentage of the reaction. Make sure the reaction mixture is below the liquid level in the bath and that the. Diy brick rocket stove cooking without electrical power duration. If you will be calculating actual and theoretical yield, be sure to record how much salicylic acid you actually measured add 6 ml of acetic anhydride and 58 drops of 85% phosphoric acid to the flask. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes.
The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. A knowledge organiser on the a level chemistry practical preparation of aspirin from 2hydroxybenzoic acid and ethanoic anhydride using a phosphoric acid catalyst. Prepare a sample of cuprammonium rayon threads from filter paper. Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. The purpose of this experiment was to make aspirin via esterification, and to determine the percent yield we as a lab group made. In this experiment, a sample of acetylsalicylic acid is prepared by acetylation of. Variation of conductance with temperature in electrolytes. Pdf this aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic. E29 preparation of aspirin acetylsalicylic acid and thin. One of the most consumed drugs production in the us is 10 million kgyear aspirin. The synthesis of aspirin chemistry standard level lab report data collection and processing and conclusion and evaluation date. You will be able to see how two very different organic compounds can be made from the same common starting material. Preparation of pure and dry sample of aspirin youtube.
After germany lost world war i, bayer was forced to give it up as part of the treaty of versailles in 1919. A knowledge organiser on the alevel chemistry practical preparation of aspirin from 2hydroxybenzoic acid and ethanoic anhydride using a phosphoric acid catalyst. Synthesis of aspirin synthesis purification characterization. The starting material, for this synthesis, is 2hydroxybenzoic acid salicylic acid. Synthesis and recrystallization of aspirin lab report. Tlc can be used to assess the course of a reaction, to assess the purity of a sample and also to. Synthesis of aspirin lab report 2989 words bartleby. As part of your a level course you will be expected to prepare an organic solid, so even if youre not specifically making aspirin, a lot of the techniques and safety considerations are similar. Synthesise aspirin from 2hydroxybenzoic acid objectives to perform and explain the reactions of acid anhydrides to synthesise aspirin from 2 hydroxybenzoic acid safety specification links perform the experiment in a wellventilated room. Though aspirin has numerous benefits, there are several adverse affects as well. Pure acetyl salicylic acid aspirin synthesis chemistry ch3 o ch3 o o acetic. Analytical, transition metals, electrochemistry and organic nirtrogen chemistry. Do not lose this container or its contents, you will use them later. Aspirin is a commonly used analgesic and antipyretic.
Company replaced the phenol group with an ester group. Synthesis of aspirin experiment chemistry libretexts. Austin peay state university department of chemistry chem 1121 synthesis of aspirin and oil of wintergreen revision f8 page 3 of 7 procedure synthesis of aspirin 1. Practical 4 determination of an enthalpy of neutralisation. Aspirin background also known as acetylsalicylic acid abbreviated asa, is a salicylate drug. In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. The synthesis of aspirin from wintergreen oil a green two step synthesis of aspirin. To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid 1 to form acetylsalicylic acid 2. Aspirin is a nonsteroidal antiinflammatory nsaid drug which can be used to treat pain, fever, inflammation and heart diseases. Sp11 1021 synthesis of aspirin and oil of wintergreen. Aspirin s chemical name is acetylsalicylic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as a catalyst.
The aim of the experiment is to introduce nmr spectroscopy into a traditional undergraduate organic chemistry experiment. Aspirin is one of the milder and least expensive pain relievers available. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Salicylic acid contains a phenol group, and phenols are known to be irritating. A green undergraduate organic chemistry laboratory experiment. Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as antiinflammatory medication. You can also buy a copy of this book via the royal society of chemistry online shop for. A greener approach to aspirin synthesis using microwave. The mechanism for this synthesis provides examples of three major classes of chemical reactions. Practical 3 determination of an equilibrium constant. Home specifications contact videos books extra resources. Aspirin was first isolated by felix hoffmann, a chemist with the german company bayer in.
Organic synthesis of aspirin abstract the purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. The usefulness of functional groups will be illustrated as well as the use of nmr, ir, and melting point in characterizing a product. Aspirin blocks an enzyme called cyclooxygenase, cox1 and cox2, which is involved with the ring closure and addition of. The purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding iron iii. The first step of the synthesis involves mixing salicylic acid with ethanoic anhydride. Acetylsalicylic acid commonly known as aspirin is the most widely used drug in. It is carried out to form ester from an acid and an alcohol. This reaction is the reverse of the synthesis reaction. The synthesis and analysis of aspirin mariam elmagbri department of chemistry, american university, washington, d. The uses,doses and side effects are also in these p slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. In this twoweek experiment the important area of organic chemistry will be illustrated by the preparation and characterization of two compounds. This book contains eight freestanding activities that can be used singly or as a coherent package in a wide range of teaching and learning situations for both academic and vocational courses. When you see that prostaglandins induce inflammation, pain, and fever, what comes to mind but aspirin.
Aspirin is prepared by acetylation of salicylic acid with acetyl chloride. Thinlayer chromatography tlc is an important technique in organic chemistry. It is the twostep synthesis of aspirin starting from oil of wintergreen. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Microwaveassisted aspirin synthesis from overthecounter pain creams using naturally acidic catalysts. Synthesis of aspirin a general chemistry experiment john olmsted iii department of chemistry and biochemistry, california state university, fullerton, fullerton, ca 92834 cc c hc cc h c h h o o o r1 r2 reactive sites common core compound oil of wintergreen salicylic acid aspirin. To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. The skills by the end of the experiment you should be able to. Experiment 22 synthesis of aspirin and oil of wintergreen.
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